Fencamfamine modulates sodium, potassium-ATPase through cyclic AMP and cyclic AMP-dependent protein kinase in rat striatum

Summary. Dopamine (DA) and fencamfamine (FCF) modulatory action on Na,K-ATPase and Mg-ATPase activity were evaluated in rat striatum. DA and FCF induced a decrease in Na,K-ATPase, without affecting Mg-ATPase activity. The effect of FCF was dose-dependent from 10 to 100 μM, with an IC50 of 4.7 × 10... Ausführliche Beschreibung

1. Person: Ferreira, M. Pinto
Weitere Personen: DeLucia, R.; Aizenstein, M. Luiz; Glezer, I.; Scavone, C.
Quelle: in Journal of neural transmission Vol. 105 (1998), p. 549-560
Weitere Artikel
Format: Online-Artikel
Genre: Keywords: Fencamfamine, dopamine, cyclic AMP, Na, K-ATPase, mechanism.
Sprache: English
Veröffentlicht: 1998
Beschreibung: Online-Ressource
Online Zugang: Online
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Anmerkung: Copyright: Copyright 1998 Springer-Verlag Wien
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245 0 0 |a Fencamfamine modulates sodium, potassium-ATPase through cyclic AMP and cyclic AMP-dependent protein kinase in rat striatum  |h Elektronische Ressource 
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520 |a Summary. Dopamine (DA) and fencamfamine (FCF) modulatory action on Na,K-ATPase and Mg-ATPase activity were evaluated in rat striatum. DA and FCF induced a decrease in Na,K-ATPase, without affecting Mg-ATPase activity. The effect of FCF was dose-dependent from 10 to 100 μM, with an IC50 of 4.7 × 10−5 M. Furthermore, the effect of FCF (100 μM) increasing AMPc levels, but not GMPc, was nonadditive with that of DA (10 μM), which is consistent to a common site of action. The 8-bromo-cyclic AMP also induced a specific reduction in the Na,K-ATPase activity. The reduction of Na,K-ATPase induced by FCF (100 μM) was blocked by either SCH 23390 or sulpiride, which are D1 and D2 receptor antagonists. The decrease in striatal NA,K-ATPase activity induced by FCF was blocked by KT 5720, a selective inhibitor of cyclic AMP-dependent protein kinase (PKA), but not by KT 5823, a selective inhibitor of cyclic GMP-dependent protein kinase (PKG). Otherwise, KT 5720 or KT 5823 did not produce any change in Na,K-ATPase or Mg-ATPase activity. These data suggest that FCF reduces Na,K-ATPase activity through cyclic AMP-dependent changes in protein phosphorylation via a PKA mechanism. 
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655 7 |a Keywords: Fencamfamine  |2 gnd 
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655 7 |a mechanism.  |2 gnd 
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700 1 |a DeLucia, R. 
700 1 |a Aizenstein, M. Luiz 
700 1 |a Glezer, I. 
700 1 |a Scavone, C. 
773 0 8 |i in  |t Journal of neural transmission  |g Vol. 105 (1998), p. 549-560  |q 105<549-560  |w (DE-601)NLEJ188994017  |x 1435-1463 
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