Hepatocyte nuclear factor-1a gene and non-insulin-dependent diabetes mellitus in the Japanese population

Abstract Recently, hepatocyte nuclear factor-1α (HNF-1α, which is encoded by the TCF1 gene) mutations were reported in a subset of patients with maturity onset diabetes of the young (MODY3). We studied the contribution of TCF1 to genetic susceptibility to common non-insulin-dependent diabetes mell... Ausführliche Beschreibung

1. Person: Babaya, N.
Weitere Personen: Ikegami, H.; Kawaguchi, Y.; Fujisawa, T.; Nakagawa, Y.; Hamada, Y.; Hotta, M.; Ueda, H.; Shintani, M.; Nojima, K.; Kawabata, Y.; Ono, M.; Yamada, K.; Shen, G.-Q.; Fukuda, M.; Ogihara, T.
Quelle: in Acta diabetologica Vol. 35 (1998), p. 150-153
Weitere Artikel
Format: Online-Artikel
Genre: Key words Non-insulin-dependent diabetes mellitus, MODY, Hepatocyte nuclear factor-1α, Genetics, Microsatellite polymorphism
Sprache: English
Veröffentlicht: 1998
Beschreibung: Online-Ressource
Online Zugang: Online
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Anmerkung: Copyright: Copyright 1998 Springer-Verlag Berlin Heidelberg
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245 0 0 |a Hepatocyte nuclear factor-1a gene and non-insulin-dependent diabetes mellitus in the Japanese population  |h Elektronische Ressource 
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520 |a Abstract Recently, hepatocyte nuclear factor-1α (HNF-1α, which is encoded by the TCF1 gene) mutations were reported in a subset of patients with maturity onset diabetes of the young (MODY3). We studied the contribution of TCF1 to genetic susceptibility to common non-insulin-dependent diabetes mellitus (type 2) in Japanese subjects by investigating allelic association with type 2 diabetes use of three markers. We also studied the frequency of the G191D mutation, the only mutation of TCF1 reported so far in late-onset type 2 diabetes. A total of 356 subjects were studied. There were no significant differences in allele frequency of the three markers between patients with type 2 diabetes and control subjects. A G191D mutation was not found in the subjects studied, giving a frequency of less than 0.4% in common type 2 diabetes. The lack of association of type 2 diabetes with three markers in and near TCF1 suggests that mutations in TCF1 derived from a limited number of founders are not a major cause of common type 2 diabetes even in the genetically homogeneous Japanese population. The data also indicate that the G191D mutation in TCF1 plays little, if any, role in susceptibility to common type 2 diabetes in the Japanese. 
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655 7 |a Key words Non-insulin-dependent diabetes mellitus  |2 gnd 
655 7 |a MODY  |2 gnd 
655 7 |a Hepatocyte nuclear factor-1α  |2 gnd 
655 7 |a Genetics  |2 gnd 
655 7 |a Microsatellite polymorphism  |2 gnd 
689 0 0 |a Key words Non-insulin-dependent diabetes mellitus 
689 0 1 |a MODY 
689 0 2 |a Hepatocyte nuclear factor-1α 
689 0 3 |a Genetics 
689 0 4 |a Microsatellite polymorphism 
689 0 |5 DE-601 
700 1 |a Babaya, N. 
700 1 |a Ikegami, H. 
700 1 |a Kawaguchi, Y. 
700 1 |a Fujisawa, T. 
700 1 |a Nakagawa, Y. 
700 1 |a Hamada, Y. 
700 1 |a Hotta, M. 
700 1 |a Ueda, H. 
700 1 |a Shintani, M. 
700 1 |a Nojima, K. 
700 1 |a Kawabata, Y. 
700 1 |a Ono, M. 
700 1 |a Yamada, K. 
700 1 |a Shen, G.-Q. 
700 1 |a Fukuda, M. 
700 1 |a Ogihara, T. 
773 0 8 |i in  |t Acta diabetologica  |g Vol. 35 (1998), p. 150-153  |q 35<150-153  |w (DE-601)NLEJ188992456  |x 1432-5233 
856 4 0 |u http://dx.doi.org/10.1007/s005920050120 
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951 |a AR 
952 |d 35  |j 1998  |c 3  |h 150-153  |g 4 

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