Xenotransplantation of the kidney: a pediatric perspective

Abstract  The major factor limiting the application of allotransplantation for the treatment of renal failure is a severe shortage of donor organs. One approach to overcoming this limitation is the use of kidneys from animals for clinical transplantation, that is xenotransplantation. Although of i... Ausführliche Beschreibung

1. Person: Platt, J. L.
Quelle: in Pediatric nephrology : journal of the International Pediatric Nephrology Association Vol. 13 (1999), p. 966-973
Weitere Artikel
Format: Online-Artikel
Genre: Key words Transplantation, Xenotransplantation, Natural antibodies, Complement, Hyperacute rejection, Acute vascular rejection, Endothelium
Sprache: English
Veröffentlicht: 1999
Beschreibung: Online-Ressource
Online Zugang: Online
Volltext
Tags: Hinzufügen
Keine Tags. Fügen Sie den ersten Tag hinzu!
Anmerkung: Copyright: Copyright 1999 IPNA - International Pediatric Nephrology Association New York, USA
LEADER 02858nma a2200469 c 4500
001 NLEJ205947247
003 DE-601
005 20110128225124.0
007 cr uuu---uuuuu
008 070528s1999 000 0 eng d
016 7 |a 14630047  |2 DE-600 
040 |b ger  |c GBVCP 
041 0 |a eng 
084 |a soj  |2 natliz 
245 0 0 |a Xenotransplantation of the kidney: a pediatric perspective  |h Elektronische Ressource 
300 |a Online-Ressource 
500 |a Copyright: Copyright 1999 IPNA - International Pediatric Nephrology Association New York, USA 
520 |a Abstract  The major factor limiting the application of allotransplantation for the treatment of renal failure is a severe shortage of donor organs. One approach to overcoming this limitation is the use of kidneys from animals for clinical transplantation, that is xenotransplantation. Although of interest for many years, the application of xenotransplantation has been prevented because of the devastating immune responses of the recipient against the graft. Research conducted in recent years has elucidated the immune mechanisms underlying the rejection of xenografts and has led to the development of incisive therapeutic strategies, including the genetic engineering of donor animals. Success in dealing with the xenogeneic immune response has encouraged the view that xenotransplantation might be feasible in the near future. It also raises consideration of two additional hurdles, the potential limitations of xenogeneic kidneys as physiological replacement for human kidneys and the possibility that the animal organ might transfer infectious organisms to the recipient and to the wider population. This paper reviews recent progress in the field of xenotransplantation of the kidney and offers a perspective on the hurdles to clinical application that remain. 
533 |a Online edition  |f Springer Online Journal Archives 1860-2002 ; 041039-1 
655 7 |a Key words Transplantation  |2 gnd 
655 7 |a Xenotransplantation  |2 gnd 
655 7 |a Natural antibodies  |2 gnd 
655 7 |a Complement  |2 gnd 
655 7 |a Hyperacute rejection  |2 gnd 
655 7 |a Acute vascular rejection  |2 gnd 
655 7 |a Endothelium  |2 gnd 
689 0 0 |a Key words Transplantation 
689 0 1 |a Xenotransplantation 
689 0 2 |a Natural antibodies 
689 0 3 |a Complement 
689 0 4 |a Hyperacute rejection 
689 0 5 |a Acute vascular rejection 
689 0 6 |a Endothelium 
689 0 |5 DE-601 
700 1 |a Platt, J. L. 
773 0 8 |i in  |t Pediatric nephrology : journal of the International Pediatric Nephrology Association  |g Vol. 13 (1999), p. 966-973  |q 13<966-973  |w (DE-601)NLEJ188983775  |x 1432-198X 
856 4 0 |u http://dx.doi.org/10.1007/s004670050738 
901 |a OLC 
912 |a ZDB-1-SOJ 
912 |a GBV_NL_ARTICLE 
951 |a AR 
952 |d 13  |j 1999  |c 9  |h 966-973  |g 8 

Ähnliche Einträge

Keine ähnlichen Titel gefunden

Privacy Notice Ask a Librarian New Acquisitions