Phenotypic characterization of 3H-thymidine incorporating cells in rheumatoid arthritis synovial membrane

Summary Tritiated-thymidine incorporating cells in synovial tissue samples from ten patients with definite or classic rheumatoid arthritis (RA) were studied by combining two techniques. Tritiated-thymidine-labelled cells were seen in autoradiography and simultaneously the subtype of them was determi... Ausführliche Beschreibung

1. Person: Nykänen, P.
Weitere Personen: Bergroth, V.; Raunio, P.; Nordström, D.; Konttinen, Y. T.
Quelle: in Rheumatology international : clinical and experimental investigations Vol. 6 (1986), p. 269-271
Weitere Artikel
Format: Online-Artikel
Genre: Autoradiography, Immunoperoxidase, Rheumatoid arthritis, Synovial membrane, 3H-thymidine incorporating cells, Monoclonal antibodies
Sprache: English
Veröffentlicht: 1986
Beschreibung: Online-Ressource
Online Zugang: Online
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Anmerkung: Copyright: Copyright 1986 Springer-Verlag
Zusammenfassung: Summary Tritiated-thymidine incorporating cells in synovial tissue samples from ten patients with definite or classic rheumatoid arthritis (RA) were studied by combining two techniques. Tritiated-thymidine-labelled cells were seen in autoradiography and simultaneously the subtype of them was determined with immunoperoxidase staining using monoclonal antibodies. Tritiated-thymidine-labelled cells comprised 0.8±0.4% of all the inflammatory cells in RA synovial membrane. Of all 3H-thymidine-labelled cells 34±17% were positive for OKT8 and 19±8% for OKT4 monoclonal antibodies. OKM1-positive cells comprised 7±3% of all 3H-thymidine labelled cells, whereas only a few (3±4%) of them were positive for pan-B monoclonal antibody. This study emphasizes the importance of activated OKT8 lymphocytes in RA synovial membrane.
ISSN: 1437-160X

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