Phase II study of mitomycin, ifosfamide and cisplatin in adenocarcinoma of the oesophagus

Abstract  We evaluated the effect of brief neoadjuvant chemotherapy in patients with apparently operable adenocarcinoma of the oesophagus. Two courses of mitomycin (6 mg/m2), ifosfamide (3 g/m2) and cisplatin (50 mg/m2; MIC) were given followed by evaluation of response by barium swallow and... Ausführliche Beschreibung

1. Person: Allen, Simon M.
Weitere Personen: Duffy, John P.; Darnton, S. Jane; Cullen, Michael H.; Matthews, H. R.
Quelle: in Cancer chemotherapy and pharmacology : CCP Vol. 37 (1996), p. 496-498
Weitere Artikel
Format: Online-Artikel
Genre: Key words Adenocarcinoma, Chemotherapy, Surgery, Oesophagus
Sprache: English
Veröffentlicht: 1996
Beschreibung: Online-Ressource
Online Zugang: Online
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Anmerkung: Copyright: Copyright 1996 Springer-Verlag Berlin Heidelberg
Zusammenfassung: Abstract  We evaluated the effect of brief neoadjuvant chemotherapy in patients with apparently operable adenocarcinoma of the oesophagus. Two courses of mitomycin (6 mg/m2), ifosfamide (3 g/m2) and cisplatin (50 mg/m2; MIC) were given followed by evaluation of response by barium swallow and computed tomography scan. Of 20 patients, 17 completed both courses and 4 (20%) showed a partial response. Toxicity was generally mild and consisted principally of nausea and vomiting. Altogether, 15 patients were surgically explored; resection was completed in 12 patients, 3 of whom died in hospital (25%). Neoadjuvant therapy with MIC offers no advantage over surgery alone.
ISSN: 1432-0843

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