Chronic immune thrombocytopenic purpura — Immunological analyses of a patient pre- and post-HIV seroconversion

Summary A seven year follow-up of immune parameters is reported for a patient with chronic immune thrombocytopenic purpura (ITP) pre and post human immunodeficiency virus (HIV) seroconversion. Therapies such as intravenous IgG, prednison, vincristine, or Ciclosporin A had no clear-cut beneficial eff... Ausführliche Beschreibung

1. Person: Späth, P. J.
Weitere Personen: Elisa, A.; Bühlmann, U.; Luginbühl, L.; Imbach, P.
Quelle: in Annals of hematology Vol. 59 (1989), p. 115-120
Weitere Artikel
Format: Online-Artikel
Genre: Chronic immune thrombocytopenic purpura, Human immunodeficiency virus infection, Complement, Splenectomy
Sprache: English
Veröffentlicht: 1989
Beschreibung: Online-Ressource
Online Zugang: Online
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Anmerkung: Copyright: Copyright 1989 Springer-Verlag
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520 |a Summary A seven year follow-up of immune parameters is reported for a patient with chronic immune thrombocytopenic purpura (ITP) pre and post human immunodeficiency virus (HIV) seroconversion. Therapies such as intravenous IgG, prednison, vincristine, or Ciclosporin A had no clear-cut beneficial effect on platelet counts. A long-term normalization of platelet counts was achieved by splenectomy. At splenectomy the patient was seropositive for HIV, most likely transmitted by blood products received half a year prior to laparatomy. Mean plasma levels of the second component of complement, C2, were half of the normal values prior to and within the lowest normal range post HIV seroconversion. Nevertheless, the T cell-dependent B cell response to HIV, which is dependent on the activation of C3 via the classical pathway of complement, was normal: Western blot analysis of total IgG and of IgG subclass responses to individual HIV antigens proved to be unimpaired. 
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