Effects of scopolamine on delayed-matching-to-sample and paired associates tests of visual memory and learning in human subjects: comparison with diazepam and implications for dementia

Abstract Two experiments examined dose-related effects of 200, 400 and 600 μg scopolamine (n = 24, SC) and 5 and 10 mg diazepam (n = 6, PO) on parallel tests of visual memory and learning taken from the CANTAB battery. Scopolamine significantly impaired accuracy of performance on a dela...yed matching to sample test of visual recognition memory in a dose-and delay-dependent manner, but had only marginal decremental effects on a test of visuospatial paired associates learning. Scopolamine significantly lengthened decision times in a visual search matching to sample task at the 400 and 600 μg doses, without significantly affecting accuracy. The drug also impaired performance on tests of spatial (on accuracy and response time measures) and pattern (on response time only) memory. Most of the deleterious effects on scopolamine were removed by covariance analyses with indices of subjective sedation, but the effects of delayed matching accuracy and latency remained. By contrast, diazepam significantly impaired paired associates learning but affected delayed matching to sample in a delay-independent manner. These results suggest that scopolamine can produce selective deficits in tests of short-term visual recognition memory which do not depend on overall impairments in arous Ausführliche Beschreibung Beschreibung ausblenden

1. Person:	Robbins, T. W.
Weitere Personen:	Semple, J.; Kumar, R.; Truman, M. I.; Shorter, J.; Ferraro, A.; Fox, B.; McKay, G.; Matthews, K.
Quelle:	in Psychopharmacology Vol. 134 (1997), p. 95-106 Weitere Artikel
Format:	Online-Artikel
Genre:	Key words Scopolamine, Diazepam, Memory, Learning, Benzodiazepine, Acetylcholine, Arousal, Attention, Dementia
Sprache:	English
Veröffentlicht:	1997
Beschreibung:	Online-Ressource
Online Zugang:	Online
Tags:	Hinzufügen Keine Tags. Fügen Sie den ersten Tag hinzu!
Anmerkung:	Copyright: Copyright 1997 Springer-Verlag Berlin Heidelberg