Familial risk and genetic susceptibility for breast cancer

Abstract Clinical observations suggest that breast cancer is occasionallyinherited as an autosomal dominant disease in families. Epidemiologic studies consistently have shown that a history of breast cancer in a first-degree relative increases a woman's risk of breast cancer when compared with the g... Ausführliche Beschreibung

1. Person: Eby, Nancy
Weitere Personen: Chang-Claude, Jenny; Timothy Bishop, D.
Quelle: in Cancer causes & control : CCC Vol. 5 (1994), p. 458-470
Weitere Artikel
Format: Online-Artikel
Genre: Breast neoplasms, case-control studies, familial risk, genetics, pedigree analysis
Sprache: English
Veröffentlicht: 1994
Beschreibung: Online-Ressource
Online Zugang: Online
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Anmerkung: Copyright: Copyright 1994 Rapid Communications of Oxford Ltd
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520 |a Abstract Clinical observations suggest that breast cancer is occasionallyinherited as an autosomal dominant disease in families. Epidemiologic studies consistently have shown that a history of breast cancer in a first-degree relative increases a woman's risk of breast cancer when compared with the general population. The risk is similar if a mother or sister is affected and is increased further if both are affected. The difficulty with such an observation is that in itself it does not clarify the nature of the true underlying risk factors which could be genetic or due to the aggregation of environmental risk factors in families. Complex segregation analysis of breast cancer aggregation in families suggests that breast cancer susceptibility is due to an autosomal dominant inheritance of one or more rare genes in a few families in which carriers have a high probability of developing the disease perhaps as great as 100 percent. Close linkage of a breast-cancer-susceptibility gene (BRCA1), between markers of the chromosomal region 17q12-q21 on the long arm of chromosome 17, with breast cancer recently has been reported. Families linked to BRCA1 were more likely to have early onset of breast cancer or have breast and ovarian cancer in the family. It is likely that other genes play a role in the unlinked breastcancer families. Both the epidemiologic and genetic data suggest that breast cancer is a heterogeneous disease. 
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655 7 |a Breast neoplasms  |2 gnd 
655 7 |a case-control studies  |2 gnd 
655 7 |a familial risk  |2 gnd 
655 7 |a genetics  |2 gnd 
655 7 |a pedigree analysis  |2 gnd 
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700 1 |a Timothy Bishop, D. 
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952 |d 5  |j 1994  |c 5  |h 458-470  |g 13 

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