Laser Raman spectroscopy of a complementary base pair in the Hoogsteen configuration

Cocrystallization of m^9Ade and m^1Thy from water yielded crystals of the Hoogsteen base pair, m^9Ade . m^1Thy, as demonstrated by X-ray diffraction data. The Raman spectrum of the Hoogsteen base pair in the crystalline state was obtained and compared to the crystals of the individual monomers. Freq... Ausführliche Beschreibung

1. Person: Strobel, J.L.
Weitere Personen: Scovell, W.M.
Quelle: in BBA Section Nucleic Acids And Protein Synthesis Vol. 608, No. 2 (1980), p. 201-214
Weitere Artikel
Format: Online-Artikel
Genre: Methyladenine, Methylthymine, Hoogsteen configuration, Base pairing, Raman spectroscopy
Sprache: English
Veröffentlicht: 1980
Beschreibung: Online-Ressource
Online Zugang: Online
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Anmerkung: Copyright: Copyright (c) 2002 Elsevier Science B.V.
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520 |a Cocrystallization of m^9Ade and m^1Thy from water yielded crystals of the Hoogsteen base pair, m^9Ade . m^1Thy, as demonstrated by X-ray diffraction data. The Raman spectrum of the Hoogsteen base pair in the crystalline state was obtained and compared to the crystals of the individual monomers. Frequency changes between the heterobase dimer and both m^9Ade and m^1Thy are indicative of the base pairing interaction. Utilizing previously reported vibrational analyses for m^9Ade, the frequency changes are clearly associated with modes involving the internal coordinates most sensitive to a Hoogsteen hydrogen bonding interaction. The spectrum of an equimolar mixture of e^9Ade and ch^1Ura in CHCl"3 was also compared to the spectrum of the separate monomers in solution. The numerous frequency shifts and band intensity changes observed in the mixture from that of the individual monomers suggest a cyclic dimer is formed although the nature of the base pairing interaction is not clear. 
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700 1 |a Scovell, W.M. 
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