On the inhibitory action of mersalyl on microsomal drug oxidation: A rigid organization of the electron transport chain

The organic mercurial, mersalyl, causes a 50% inhibition of TPNH-cytochrome c reductase activity, TPNH-cytochrome P-450 reductase activity, and ethylmorphine N-demethylation in rat liver microsomes at concentrations of about 25 mμmoles/mg microsomal protein. The K"i (mersalyl) proved to be independ... Ausführliche Beschreibung

1. Person: Franklin, M.R.
Weitere Personen: Estabrook, R.W.
Quelle: in Archives of Biochemistry and Biophysics Vol. 143, No. 1 (1971), p. 318-329
Weitere Artikel
Format: Online-Artikel
Sprache: English
Veröffentlicht: 1971
Beschreibung: Online-Ressource
Online Zugang: Online
Volltext
Tags: Hinzufügen
Keine Tags. Fügen Sie den ersten Tag hinzu!
Anmerkung: Copyright: Copyright (c) 2005 Elsevier (USA)
LEADER 02144nma a2200325 c 4500
001 NLEJ183895452
003 DE-601
005 20151015020111.0
007 cr uuu---uuuuu
008 070506s1971 000 0 eng d
016 7 |a 1461378-5  |2 DE-600 
024 8 |a 0003-9861(71)90213-X 
035 |a (DE-599)GBVNLZ183895452 
040 |b ger  |c GBVCP 
041 0 |a eng 
084 |a sdj  |2 natliz 
245 0 0 |a On the inhibitory action of mersalyl on microsomal drug oxidation: A rigid organization of the electron transport chain  |h Elektronische Ressource 
300 |a Online-Ressource 
500 |a Copyright: Copyright (c) 2005 Elsevier (USA) 
520 |a The organic mercurial, mersalyl, causes a 50% inhibition of TPNH-cytochrome c reductase activity, TPNH-cytochrome P-450 reductase activity, and ethylmorphine N-demethylation in rat liver microsomes at concentrations of about 25 mμmoles/mg microsomal protein. The K"i (mersalyl) proved to be independent of whether the overall hydroxylation activity was enhanced by the addition of DPNH, or an increased ionic strength; or was inhibited by carbon monoxide. Mersalyl, at a concentration of 25 mμmoles/mg protein, caused no extensive conversion of cytochrome P-450 to P-420. Studies on the pattern of inhibition suggest a rigid electron-transport system linking a single molecule of TPNH-cytochrome c reductase to a number of molecules of cytochrome P-450 contained within a multicomponent complex and that reducing equivalents can be transferred only within a single enzyme complex with no demonstrable electron transfer interactions between the components of different complexes. 
533 |a Online edition  |f Elsevier Journal Backfiles on ScienceDirect 1907 - 2002 ; 041023-8 
700 1 |a Franklin, M.R. 
700 1 |a Estabrook, R.W. 
773 0 8 |i in  |t Archives of Biochemistry and Biophysics  |d Amsterdam : Elsevier  |g Vol. 143, No. 1 (1971), p. 318-329  |q 143:1<318-329  |w (DE-601)NLEJ177020539  |x 0003-9861 
856 4 0 |u http://dx.doi.org/10.1016/0003-9861(71)90213-X 
901 |a OLC 
912 |a ZDB-1-SDJ 
912 |a GBV_NL_ARTICLE 
951 |a AR 
952 |d 143  |j 1971  |e 1  |h 318-329 

Ähnliche Einträge

Keine ähnlichen Titel gefunden

Privacy Notice Ask a Librarian New Acquisitions