A Transition Metal Complex (Venus Flytrap Cluster) for Radioimmunodetection and Radioimmunotherapy

A novel transition metal complex, Venus flytrap cluster (VFC), is described for the preparation of radiolabeled antibodies. VFC contained57Co, which was held tightly between the faces of two covalently bridged carborane ligands by cluster bonding of the metal with appropriate ligand orbitals. Anti-c...arcinoembryonic antigen monoclonal antibody T84.66 was conjugated to57Co-VFC with full retention of immunological activity. Biodistribution studies in nude mice bearing carcinoembryonic antigen-producing tumors showed excellent tumor localization of57Co-VFC-T84.66. The accumulation of radionuclide in normal liver was low and independent of dose, which may reflect the stability of the radionuclide complex. These results presage the use of VFC systems for binding transition metals that are clinically useful for radio-immunodiagnosis and radioimmunotherapy. Ausführliche Beschreibung Beschreibung ausblenden

1. Person:	Paxton, Raymond J.
Weitere Personen:	Beatty, Barbara G. verfasserin; Hawthorne, M. Frederick verfasserin; Varadarajan, Aravamuthan verfasserin; Williams, Lawrence E. verfasserin; Curtis, Frederick L. verfasserin; Knobler, Carolyn B. verfasserin; Beatty, J. David verfasserin; Shiveley, John E. verfasserin
Quelle:	in Proceedings of the National Academy of Sciences of the United States of America Vol. 88, No. 8 (1991), p. 3387-3391 Weitere Artikel
Format:	Online-Artikel
Sprache:	English
Veröffentlicht:	1991
Beschreibung:	Online-Ressource
Schlagworte:	research-article Medical Sciences Carborane Radionuclides Colon Cancer Carcinoembryonic Antigen Monoclonal Antibody
Online Zugang:	Volltext
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Anmerkung:	Copyright: Copyright 1991 The National Academy of Sciences of the United States of America