Detection and formation scenario of citric acid, pyruvic acid, and other possible metabolism precursors in carbonaceous meteorites

Carbonaceous meteorites deliver a variety of organic compounds to Earth that may have played a role in the origin and/or evolution of biochemical pathways. Some apparently ancient and critical metabolic processes require several compounds, some of which are relatively labile such as keto acids. Ther...efore, a prebiotic setting for any such individual process would have required either a continuous distant source for the entire suite of intact precursor molecules and/or an energetic and compact local synthesis, particularly of the more fragile members. To date, compounds such as pyruvic acid, oxaloacetic acid, citric acid, isocitric acid, and α-ketoglutaric acid (all members of the citric acid cycle) have not been identified in extraterrestrial sources or, as a group, as part of a "one pot" suite of compounds synthesized under plausibly prebiotic conditions. We have identified these compounds and others in carbonaceous meteorites and/or as low temperature (laboratory) reaction products of pyruvic acid. In meteorites, we observe many as part of three newly reported classes of compounds: keto acids (pyruvic acid and homologs), hydroxy tricarboxylic acids (citric acid and homologs), and tricarboxylic acids. Laboratory syntheses using 13C-labeled reactants demonstrate that one compound Ausführliche Beschreibung Beschreibung ausblenden

1. Person:	Cooper, George
Weitere Personen:	Reed, Chris verfasserin; Nguyen, Dang verfasserin; Carter, Malika verfasserin; Wang, Yi verfasserin
Quelle:	in Proceedings of the National Academy of Sciences of the United States of America Vol. 108, No. 34 (2011), p. 14015-14020 Weitere Artikel
Format:	Online-Artikel
Sprache:	English
Veröffentlicht:	2011
Beschreibung:	Online-Ressource
Schlagworte:	research-article
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