Tiptoeing to Chromosome Tips: Facts, Promises and Perils of Today's Human Telomere Biology

The past decade has witnessed an explosion of knowledge concerning the structure and function of chromosome terminal structures-telomeres. Today's telomere research has advanced from a pure descriptive approach of DNA and protein components to an elementary understanding of telomere metabolism, and ... Ausführliche Beschreibung

1. Person: Fajkus, J.
Weitere Personen: Šimíčková, M. verfasserin; Maláska, J. verfasserin
Quelle: in Philosophical transactions Vol. 357, No. 1420 (2002), p. 545-562
Weitere Artikel
Format: Online-Artikel
Sprache: English
Veröffentlicht: 2002
Beschreibung: Online-Ressource
Schlagworte: research-article
Human Telomere
Telomerase Regulation
Cancer
Inhibition
Cell Engineering
Tissue Engineering
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Anmerkung: Copyright: Copyright 2001-2002 The Royal Society
Zusammenfassung: The past decade has witnessed an explosion of knowledge concerning the structure and function of chromosome terminal structures-telomeres. Today's telomere research has advanced from a pure descriptive approach of DNA and protein components to an elementary understanding of telomere metabolism, and now to promising applications in medicine. These applications include 'passive' ones, among which the use of analysis of telomeres and telomerase (a cellular reverse transcriptase that synthesizes telomeres) for cancer diagnostics is the best known. The 'active' applications involve targeted downregulation or upregulation of telomere synthesis, either to mortalize immortal cancer cells, or to rejuvenate mortal somatic cells and tissues for cellular transplantations, respectively. This article reviews the basic data on structure and function of human telomeres and telomerase, as well as both passive and active applications of human telomere biology.
ISSN: 0962-8436

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