Characterization of Potential Endocrine-Related Health Effects at Low-Dose Levels of Exposure to PCBs
This article addresses issues related to the characterization of endocrine-related health effects resulting from low-level exposures to polychlorinated biphenyls (PCBs). It is not intended to be a comprehensive review of the literature but reflects workshop discussions. "The Characterizing the Effec... Ausführliche Beschreibung
|1. Person:||Brouwer, Abraham|
|Weitere Personen:||Longnecker, Matthew P. verfasserin; Birnbaum, Linda S. verfasserin; Cogliano, Jim verfasserin; Kostyniak, Paul verfasserin; Moore, Jack verfasserin; Schantz, Suzan verfasserin; Winneke, Gerhard verfasserin|
in Environmental health perspectives : EHP Vol. 107 (1999), p. 639-649
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This article addresses issues related to the characterization of endocrine-related health effects resulting from low-level exposures to polychlorinated biphenyls (PCBs). It is not intended to be a comprehensive review of the literature but reflects workshop discussions. "The Characterizing the Effects of Endocrine Disruptors on Human Health at Environmental Exposure Levels," workshop provided a forum to discuss the methods and data needed to improve risk assessments of endocrine disruptors. This article contains an overview of endocrine-related (estrogen and thyroid system) interactions and other low-dose effects of PCBs. The data set on endocrine effects includes results obtained from mechanistic methods/ and models (receptor based, metabolism based, and transport protein based), as well as from in vivo models, including studies with experimental animals and wildlife species. Other low-dose effects induced by PCBs, such as neurodevelopmental and reproductive effects and endocrine-sensitive tumors, have been evaluated with respect to a possible causative linkage with PCB-induced alterations in endocrine systems. In addition, studies of low-dose exposure and effects in human populations are presented and critically evaluated. A list of conclusions and recommendations is included.