Altered Operant Responding for Motor Reinforcement and the Determination of Benchmark Doses Following Perinatal Exposure to Low-Level 2,3,7,8-Tetrachlorodibenzo-p-Dioxin

Pregnant Holtzman rats were exposed to a single oral dose of 0, 20, 60, or 180 ng/kg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the 18th day of gestation. Their adult female offspring were trained to respond on a lever for brief opportunities to run in specially designed running wheels. Once they... Ausführliche Beschreibung

1. Person: Markowski, Vincent P.
Weitere Personen: Zareba, Grazyna verfasserin; Stern, Sander verfasserin; Cox, Christopher verfasserin; Weiss, Bernard verfasserin
Quelle: in Environmental health perspectives : EHP Vol. 109, No. 6 (2001), p. 621-627
Weitere Artikel
Format: Online-Artikel
Sprache: English
Veröffentlicht: 2001
Beschreibung: Online-Ressource
Schlagworte: research-article
Benchmark dose
Estrous cycle
Operant behavior
Prenatal exposure
TCDD
Wheel running
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024 7 |a 10.2307/3455037  |2 doi 
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041 0 |a eng 
100 1 |a Markowski, Vincent P. 
245 1 0 |a Altered Operant Responding for Motor Reinforcement and the Determination of Benchmark Doses Following Perinatal Exposure to Low-Level 2,3,7,8-Tetrachlorodibenzo-p-Dioxin  |h Elektronische Ressource 
300 |a Online-Ressource 
520 |a Pregnant Holtzman rats were exposed to a single oral dose of 0, 20, 60, or 180 ng/kg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the 18th day of gestation. Their adult female offspring were trained to respond on a lever for brief opportunities to run in specially designed running wheels. Once they had begun responding on a fixed-ratio 1 (FR1) schedule of reinforcement, the fixed-ratio requirement for lever pressing was increased at five-session intervals to values of FR2, FR5, FR10, FR20, and FR30. We examined vaginal cytology after each behavior session to track estrous cyclicity. Under each of the FR values, perinatal TCDD exposure produced a significant dose-related reduction in the number of earned opportunities to run, the lever response rate, and the total number of revolutions in the wheel. Estrous cyclicity was not affected. Because of the consistent dose-response relationship at all FR values, we used the behavioral data to calculate benchmark doses based on displacements from modeled zero-dose performance of 1% ( ED<sub>01</sub>) and 10% ( ED<sub>10</sub>), as determined by a quadratic fit to the dose-response function. The mean ED<sub>10</sub> benchmark dose for earned run opportunities was 10.13 ng/kg with a 95% lower bound of 5.77 ng/kg. The corresponding ED<sub>01</sub> was 0.98 ng/kg with a 95% lower bound of 0.83 ng/kg. The mean ED<sub>10</sub> for total wheel revolutions was calculated as 7.32 ng/kg with a 95% lower bound of 5.41 ng/kg. The corresponding ED<sub>01</sub> was 0.71 ng/kg with a 95% lower bound of 0.60. These values should be viewed from the perspective of current human body burdens, whose average value, based on TCDD toxic equivalents, has been calculated as 13 ng/kg. 
653 |a research-article 
653 |a Benchmark dose 
653 |a Estrous cycle 
653 |a Operant behavior 
653 |a Prenatal exposure 
653 |a TCDD 
653 |a Wheel running 
700 1 |a Zareba, Grazyna  |e verfasserin  |4 aut 
700 1 |a Stern, Sander  |e verfasserin  |4 aut 
700 1 |a Cox, Christopher  |e verfasserin  |4 aut 
700 1 |a Weiss, Bernard  |e verfasserin  |4 aut 
773 0 8 |i in  |t Environmental health perspectives : EHP  |d Research Triangle Park, N.C. [u.a.]  |g Vol. 109, No. 6 (2001), p. 621-627  |q 109:6<621-627  |w (DE-601)JST031217095  |x 0091-6765 
856 4 1 |u https://www.jstor.org/stable/3455037  |3 Volltext 
856 4 1 |u http://dx.doi.org/10.2307/3455037  |3 Volltext 
912 |a GBV_JSTOR 
951 |a AR 
952 |d 109  |j 2001  |e 6  |h 621-627 

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