Biopharmaceutical Applied Statistics Symposium: Volume 3 Pharmaceutical Applications

The topics covered include: Targeted Learning of Optimal Individualized Treatment Rules under Cost Constraints, Uses of Mixture Normal Distribution in Genomics and Otherwise, Personalized Medicine – Design Considerations, Adaptive Biomarker Subpopulation and Tumor Type Selection in Phase III Oncol... Ausführliche Beschreibung

1. Person: Peace, Karl E. [editor]
Weitere Körperschaften: SpringerLink (Online service)
Weitere Personen: Chen, Ding-Geng [editor]; Menon, Sandeep [editor]
Format: E-Buch
Sprache: English
Veröffentlicht: Singapore Springer Singapore 2018, 2018
Beschreibung: XV, 426 p. 74 illus., 46 illus. in color online resource
Ausgabe: 1st ed. 2018
Serien: ICSA Book Series in Statistics
Schlagworte: Statistics for Life Sciences, Medicine, Health Sciences
Statistical methods
Biostatistics
Statistics
Online Zugang: Volltext
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Inhaltsangabe:
  • Personalized Medicine
  • 1 Targeted Learning of Optimal Individualized Treatment Rules under Cost Constraints
  • 2 Uses of Mixture Normal Distribution in Genomics and Otherwise
  • 3 Personalized Medicine – Design Considerations
  • 4 Adaptive Biomarker Subpopulation and Tumor Type Selection in Phase III Oncology Trials
  • 5 High Dimensional Data in Genomics
  • Part II:  Novel Applications
  • 6 Synergy or Additivity - The Importance of Defining the Primary Endpoint
  • 7 Full Bayesian Adaptive Dose Finding using Toxicity Probability Interval (TPI)
  • 8 Alpha-recycling for the Analyses of Primary and Secondary Endpoints of Clinical Trials
  • 9 Expanded Interpretations of Results of Carcinogenicity Studies of Pharmaceuticals
  • 1 Clinical Trials in Orphan Drug Development
  • 11 Mediation Modeling in Randomized Trials with Non-normal Outcome Variables
  • 12 Statistical Considerations in Using Images in Clinical Trials
  • 13 Interesting Applications over 30 Years of Consulting -

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