Selective Phenotyping, Entropy Reduction, and the Mastermind game

Abstract Background With the advance of genome sequencing technologies, phenotyping, rather than genotyping, is becoming the most expensive task when mapping genetic traits. The need for efficient selective phenotyping strategies, i.e. methods to select a subset of genotyped individuals for phenotyp... Ausführliche Beschreibung

1. Person: Gagneur Julien verfasserin
Weitere Personen: Elze Markus C verfasserin; Tresch Achim verfasserin
Quelle: In BMC Bioinformatics (01.10.2011)
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Format: Online-Artikel
Sprache: English
Veröffentlicht: 2011
Beschreibung: Online-Ressource
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  Creative Commons License Source: Directory of Open Access Journals (DOAJ).
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520 |a Abstract Background With the advance of genome sequencing technologies, phenotyping, rather than genotyping, is becoming the most expensive task when mapping genetic traits. The need for efficient selective phenotyping strategies, i.e. methods to select a subset of genotyped individuals for phenotyping, therefore increases. Current methods have focused either on improving the detection of causative genetic variants or their precise genomic location separately. Results Here we recognize selective phenotyping as a Bayesian model discrimination problem and introduce SPARE (Selective Phenotyping Approach by Reduction of Entropy). Unlike previous methods, SPARE can integrate the information of previously phenotyped individuals, thereby enabling an efficient incremental strategy. The effective performance of SPARE is demonstrated on simulated data as well as on an experimental yeast dataset. Conclusions Using entropy reduction as an objective criterion gives a natural way to tackle both issues of detection and localization simultaneously and to integrate intermediate phenotypic data. We foresee entropy-based strategies as a fruitful research direction for selective phenotyping. 
700 0 |a Elze Markus C  |e verfasserin  |4 aut 
700 0 |a Tresch Achim  |e verfasserin  |4 aut 
773 0 8 |i In  |t BMC Bioinformatics  |g  (01.10.2011)  |w (DE-601)DOAJ000060496  |x 1471-2105 
856 4 0 |u http://dx.doi.org/10.1186/1471-2105-12-406 
856 4 0 |y DOAJ  |u https://doaj.org/article/785a9a7dbfbf4f20b291641b96fd3121 
856 4 0 |u http://www.biomedcentral.com/1471-2105/12/406 
856 4 0 |u https://doaj.org/toc/1471-2105 
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952 |j 2011  |b 01  |c 10 

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